In a small urban flat, grandma, mom, and two daughters live in partial harmony. Grandma is bed-ridden and mute, but rings a bell above her head. Her daughter Nina, a museum docent, misses male friendship and both her ex-husbands. Each fathered a daughter:
Eminent Boston Psychiatrist, Frasier Crane, last seen gracing the bars of Cheers has left his life there to start afresh in Seattle. He now has a spot as a popular radio Psychiatrist, giving him the chance to spread words of wit and wisdom to the masses.