近未来某一年，地球爆发毁灭性极大的致命病毒，从而导致全球超过半数的人口死亡。一望无际的茫茫大海，似乎成为病毒无法涉足的神域，而汤姆·坎德勒船长（埃里克·迪恩 Eric Dane 饰）所统领的阿利·伯克级驱逐舰导弹驱逐舰“内森-詹姆斯”号，则成为天罚过后漫无目的漂流并等待 赦免的诺亚方舟。为了保存有生力量，同时确保船上的两名滤过性病原体学者研制出抗毒解药，坎德勒船长违抗了美国临时政府的召唤，带着船员踏上漫漫征途。然而一路上凶险倍至，为了补给和疫苗，他们不得不停靠港口和陆地，除此之外更有他国的船舰试图抢夺解药
The fifth-year residents return for the first day of a year that will make or break their careers: Meredith faces the consequences of tampering with Derek's clinical trial and is terminated at the hospital; April tries to step up to the plate
After a governor issues an executive order to arrest the children of undocumented immigrants, the newly detained youth are offered an opportunity to have their charges dropped by volunteering to provide care to the elderly.
